In the name of of Allah the Merciful

Personalized Drug Screening for Functional Tumor Profiling

Elements in Molecular Oncology, Victoria El-Khoury, Tatiana Michel, Hichul Kim, Yong-Jun Kwon, 1009016938, 978-1009016933, 9781009016933, B0B4F3BH8Y, 9781009037235, 9781009036894, 978-1009037235, 978-1009036894

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English | 2022 | PDF

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 Despite  considerable advances in our understanding of the biology that  underlies tumor development and progression of cancer and the rapidly  evolving field of personalized medicine, cancer is still one of the  deadliest diseases. Many cancer patients have benefited from the  survival improvements observed with targeted therapies but only a small  subset of patients receiving targeted drugs experience an objective  response. Because cancer is a complex and heterogeneous disease, the  search for effective cancer treatments will need to address not only  patient-specific molecular defects but also aspects of the tumor  microenvironment. The functional tumor profiling directly measures the  cellular phenotype, in particular tumor growth, in response to drugs  using patient-derived tumor models and might be the next step toward  precision oncology. In this Element, the authors discuss the  personalized drug screening as a novel patient stratification strategy  for the determination of individualized treatment choices in oncology